Regenerative medicine practice has been getting better and better every decade and being the solution for every department in medical science. Sports medicine practice depends a lot on regenerative medicines which is platelet rich plasma on healing process of muscles, ligaments, tendon’s etc. Similarly as PPRP is known much for the healing process the hair bearing tissue healing is also a part of its efficacy and widely used by the practitioners on hair loss cases for restoration. Platelet rich plasma treatment is extremely helpful in re-structuring the hair follicular unit grafts. The growth factors released by the platelet rich plasma treatment does the healing process of the graft muscles to help in hair growth. Androgenetic alopecia is the major concern in men which causes hair loss and platelet rich plasma is the only effective solution in the initial stages of hair loss. During stage 2 of hair loss the DHT hormones slows down the growth process by shortening the life cycle of the hair which is caused by the deficit of proper blood circulation reaching the follicular unit graft. PRP treatment releases several growth factors which allows the grafts to revive back. Insulin growth factor, endothelial growth factor, Endovascular growth factor, Transforming growth factor, Platelet derived growth factor, epidermal growth factor, hepatocyte growth factor, Fibroblast growth factor are the major contribution to the tissue healing process which stabilizes hair loss and starts thickening up hair strands, it also regrows few hairs back which is in the dormant stage. PRP therapy is an 1 hour session where first topical application of local anesthesia spray is applied on the scalp and wait for it to act for 30 minutes at least, by that time the blood will be drawn from both of the arms which is 10+10 ml and captured in the Dual chamber PRP tubes which is the latest generation endotoxin and pyrogen free PRP which never gets contaminated with RBC. The tubes are then placed in the Fleta 40 advanced PRP machine and centrifuged for 15 mins. Post centrifugal process the platelets separated will be withdrawn in syringes and been injected on the scalp dividing the zones. For optimum results minimum 6 to 9 Dual chamber closed casket PRP need to be performed. In the recent innovations the closed casket dual chamber PRP id been launched by MAX hair clinic in Chennai, Bangalore, Hyderabad & Coimbatore.